Search results for " protein kinase CK2"

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CK2β-regulated signaling controls B cell differentiation and function

2023

Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. Here, we describe the first B-cell specific knockout (KO) mouse model of the β regulatory subunit of CK2. CK2βKO mice present an increase in marginal zone (MZ) and a reduction in follicular B cells, suggesting a role for CK2 in the regulation of the B cell receptor (BCR) and NOTCH2 signaling pathways. Biochemical analyses demonstrate an increased activation of the NOTCH2 pathway in CK2βKO animals, which sustains MZ B-cell development. Transcriptomic analyses indicate alterations in biological processes involved in immune response and B-cell activation. Upo…

B lymphocytegerminal centerB cell developmentprotein kinase CK2B cell development B cell receptor signaling B lymphocyte Diffuse large B cell lymphoma germinal center marginal zone protein kinase CK2ImmunologyB cell receptor signalingmarginal zoneSettore MED/05 - Patologia ClinicaImmunology and AllergyDiffuse large B cell lymphomaSettore MED/08 - Anatomia PatologicaB cell development; B cell receptor signaling; B lymphocyte; Diffuse large B cell lymphoma; germinal center; marginal zone; protein kinase CK2Frontiers in Immunology
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